Biomedical Sciences

Volume 2, Issue 1, January 2016

  • Three-Dimensional Structure of RNA-Binding Protein TLS Co-Crystallized with Biotinylated Isoxazole

    Riki Kurokawa, Toshikazu Bando

    Issue: Volume 2, Issue 1, January 2016
    Pages: 1-10
    Received: 7 April 2016
    Accepted: 13 April 2016
    Published: 3 June 2016
    DOI: 10.11648/
    Abstract: RNA-binding protein TLS with specific mutations forms insoluble precipitates in motor neurons causing neuronal degenerative diseases like amyotrophic lateral sclerosis (ALS), and frontotemporal dementia. TLS at high concentration around 10 mg/ml is prone to be precipitated even without any mutation. The mutation on TLS is supposed to induce more pr... Show More