Volume 5, Issue 3, September 2019, Page: 34-37
Anti-plasmodial Activity of a Non-protein Amino Acid Taurine
Thavamani Rajapandi, Department of Natural Sciences, Coppin State University, Baltimore MD, The United States
Kazim Ackie, Department of Natural Sciences, Coppin State University, Baltimore MD, The United States
Kavita Rajeev Hegde, Department of Natural Sciences, Coppin State University, Baltimore MD, The United States
Received: Sep. 26, 2019;       Accepted: Oct. 15, 2019;       Published: Oct. 25, 2019
DOI: 10.11648/j.bs.20190503.13      View  430      Downloads  85
Human malaria is caused by a few selected species of the genus Plasmodium. Among these, Plasmodium falciparum causes almost 90% of malaria-related mortality. Novel anti-malarial compounds are hence required to fight the anti-malarial drug-resistant P. falciparum parasites. The objective of this study is to analyze the effectiveness of Taurine (2-aminoethane sulfonic acid), a non-protein amino acid, in preventing the growth and development of both asexual and sexual stages of in vitro cultured P. falciparum parasites. We found that 200 mM concentration of Taurine almost completely (>80%) inhibited the propagation of asexual stages of P. falciparum. In contrast, it did not have any inhibitory activity against the maturation of sexual or gametocyte stages. However, the gametocytogenesis or the conversion of asexual to stage I gametocyte was blocked partially by this compound. The results suggest that derivatives of Taurine /2-aminoethane sulfonic acid could be considered to further improve the effectiveness of Taurine as an antimalarial compound against both the asexual and early sexual stages of P. falciparum.
Malaria, Plasmodium falciparum, 2-amino Ethane Sulfonic Acid (Taurine), Drug Resistance and Gametocytes
To cite this article
Thavamani Rajapandi, Kazim Ackie, Kavita Rajeev Hegde, Anti-plasmodial Activity of a Non-protein Amino Acid Taurine, Biomedical Sciences. Vol. 5, No. 3, 2019, pp. 34-37. doi: 10.11648/j.bs.20190503.13
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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